伟德国际1946bv官网

赵添堃
2023-05-29 点击: 作者: 来源:

F64C

赵添堃,副教授,硕士研究生导师

甘肃省兰州市七里河区彭家坪路36号衡鉴楼-405

课题组网站:https://www.labxing.com/-20180038

Email: zhaotiankun2006@163.com

Tel:13679480596 (微信同号)

【教育和工作经历】

2024-2025,访问学者,Instituto Superior Técnico,Universidade de Lisboa.

2019.2-今,副教授,兰州理工大学伟德国际1946源于英国

2016.2-2018.1,博士后,Texas A&M University (Prof. Marcetta Y Darensbourg)

2011.8-2015.11,博士, University of Konstanz (Prof Ulrich Groth and Prof Huhn Thomas)

2010.8-2011.7,中化(宁波)集团有限公司

2007.9-2010.6,硕士,上海大学化学系

2003.9-2007.6,本科,郑州大学药学院

【讲授课程】

药物合成反应,新药设计学,制药工程专业英语

【研究方向】

具有抗癌/抗菌活性的非铂类金属配合物设计合成与分子作用机制

【科研项目】

主持及参与国家级(No. 22267011),省部级科研项目(2025A-035;25CXJA007;25CXJA008;24CXJA005,20JR5RA470)及企业研发项目十余项。

【论文著作】

(1)Yuan, H.; Pei, M.; Lv, B.; Mei, D.; Zhou, Y.; Wang, L.; Pu, X.;Zhao, T.*2-Nitroethenyl Ferrocene as a Photosensitizer: Evaluation of Its Photodynamic Antitumor Properties. J. Organomet. Chem.2025, in press.

(2) Zhao, T.*; Mei, D.; Ma, J.; Liu, N.; Zhang, Q.; Yang, Z.; Correia, I. Anti-tumor and Cellular Mechanisms of HfIV Tetra-(8-hydroxyquinolinato) Complexes. J. Inorg. Biochem. 2025, 270, 0162-0134.

(3) Zhao, T.*; Zhang, Q.; Zhao, J.; Mei, D.; Ma, J.; Correia, I.; Yang, Z.; Kim, S.-H.; Huhn, T. Synthesis and X-ray Structure Analysis of Cytotoxic 2-picolylamino-type HfIV-bis-chelated Complexes. Dalton Trans. 2025, 54 (16), 6674–6683.

(4) Zhou, Y..; Zhao, T.*; Tao, S.; Wang, P.; Guan, Y..; Yang, K.; Chen, S..; Pu, X*. Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti-tumor Metallic Complexes. Chem. Asian J. 2024, 19 (3), e202301020.

(5) Li, S.; Zhang, X.; Zhao, T.*; Liu, N.; Zhang, Y.; Wang, P.; Yang, Z.; Huhn, T. Synthesis, in Vitro Antitumor Evaluation and Structure–Activity Relationship of Heptacoordinated Amino-bis(Phenolato) Ti(IV) Complexes Stabilized by 2,6-Dipicolinic Acid. J. Biol. Inorg. Chem. 2024, 29, 315–330.

(6) Zhao, W.; Yuan, P.; Zhang, Q.; Liu, N.; Wang, Y.; Wang, P.; Huhn, T.; Yang, Z.; Zhao, T.* Novel Bimetallic Oxido-bridged Phenolato Hafnium(IV) Complex with Enhanced Anti-tumor Activity and Aqueous Stability. Res. Chem. 2023, 6, 2211–7156.

(7) Yang, M.; Liu, N.; Wang, P.; Zhao, T.* Synthesis and Cytotoxicity Study of Water Soluble 8-hydroxyquinoline Stabilized Zirconium(IV) Complexes. Inorg. Chem. Commun. 2023, 153, 1387–7003.

(8) Zhao, T.*; Zhang, Y.; Wang, P.; Li, S.; Yang, Z.; Yang, M. Synthesis and Nitric Oxide Release Study of Dinitrosyl Cobalt Complexes. Inorg. Chem. Commun. 2023, 149, 1387–7003.

(9) Zhao, T.*; Wang, P.; Zhang, X.; Liu, N.; Zhao, W.; Zhang, Y.; Yuan, P.; Li, S.; Yang, M.; Yang, Z.; Huhn, T. Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure–Activity Relationship. Curr. Top. Med. Chem. 2023, 23 (19), 1835–1849.

(10) Zhao, T.*; Wang, P.; Liu, N.; Zhao, W.; Yang, M.; Li, S.; Yang, Z.; Sun, B.; Huhn, T. Synthesis and X-ray Structure Analysis of Cytotoxic Heptacoordinated Salan Hafnium(IV) Complexes Stabilized with 2,6-Dipicolinic Acid. J. Inorg. Biochem. 2023, 240, 112094.

(11) Zhao, T.*; Wang, P., Liu, N., Li, S., Yang, M., & Yang, Z, Facile synthesis of [ONON] type titanium(IV) bis-chelated complexes in alcoholic solvents and evaluation of anti-tumor activity, J. Inorg. Biochem, 2022, 235, 111925.

(12) Zhao, T.*, Wang, P., Ji, M., Li, S., Yang, M. and Pu, X. The crystal structure of 1,1′-(((2 (dimethylamino)ethyl)azanediyl)bis(methylene)) bis(naphthalen-2-olato-κ4 N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)- titanium(IV) ─ dichloromethane (2/1), C33H29N3O6Ti. Z. Kristallogr. - New Cryst. Struct.2021, 236 (5), 985-987.

(13) 赵添堃*,王鹏, 姬明宇, 杨明俊, 蒲秀瑛. 具抗癌活性的茂环及β-二酮钛、锆和铪配合物的研究进展.化学通报,2021, 84(11), 1163-1172.

(14) Zhao, T.*, Ji, M., Peng Wang, Li, S., Pu, X. and Yang, M., Polymorphism in acetyl-CoA synthase mimic complex [NiN2S2-(W(CO)5)2], Polyhedron, 2021, 209, 115448.

(15) 赵添堃*, 王鹏, 姬明宇, 李善家, 杨明俊, 蒲秀瑛. Salan钛双齿配合物的Sonogashira合成后修饰反应研究.化学学报, 2021, 79(11),1385-1393+1415.

(16) Zhao, T.*, Li, S., Wang, P., Ji, M., Yang, M. & Pu, X. The crystal structure of 6,6′-(((2-(dimethylamino)ethyl)azanediyl)bis(methylene))bis(benzo[d][1,3]dioxol-5-ol ato-κ4N,N′,O,O′)-(pyridine-2,6-dicarboxylato-N,O,O′)-titanium(IV)-dichloromethane(1/1), C27H25N3O10Ti. Z. Kristallogr. - New Cryst. Struct, 2021, 236(6), 1165-1167.